{"id":17016,"date":"2026-07-02T07:34:59","date_gmt":"2026-07-02T10:34:59","guid":{"rendered":"https:\/\/www.brainn.org.br\/?p=17016"},"modified":"2026-07-02T07:34:59","modified_gmt":"2026-07-02T10:34:59","slug":"genetics-and-molecular-biology-50-anos-artigo-de-iscia-lopes-cendes-esta-entre-os-mais-citados","status":"publish","type":"post","link":"https:\/\/www.brainn.org.br\/en\/genetics-and-molecular-biology-50-anos-artigo-de-iscia-lopes-cendes-esta-entre-os-mais-citados\/","title":{"rendered":"Genetics and Molecular Biology 50 years: article by Iscia Lopes-Cendes is among the most cited"},"content":{"rendered":"Paper by BRAINN researchers on noncoding RNAs is one of the most cited in the fifty\u2011year history of the scientific journal.<\/em><\/p>\n

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The scientific journal Genetics and Molecular Biology<\/em><\/strong><\/a><\/span> (GMB), published by the Brazilian Society of Genetics, is celebrating 50 years<\/strong> in 2027. To mark this occasion, the journal is highlighting the 50 most cited papers<\/em> in its history. Among them is the review ‘The new world of RNAs<\/em>‘, which included contributions from three researchers of the CEPID BRAINN<\/strong>, Andr\u00e9 Schwambach Vieira<\/span><\/strong><\/a>, Simoni Helena Avansini<\/strong><\/a><\/span> and Iscia Lopes-Cendes<\/strong><\/a><\/span>.<\/p>\n

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The New World of RNAs<\/strong><\/em><\/h2>\n

Published in 2013, the article is a didactic review on noncoding RNAs (ncRNAs)<\/strong>, with a primary focus on microRNAs (miRNAs)<\/strong> and small interfering RNAs<\/em> (siRNAs)<\/strong>.<\/p>\n

In the article, the authors explain miRNA biogenesis and how these molecules can regulate gene expression, either through mRNA degradation or by inhibiting translation. The text also describes the different classes of ncRNAs, the complexity of regulatory networks, and the association between miRNA dysregulation and diseases such as cancer.<\/p>\n

The review further addresses siRNAs<\/strong> and the mechanism of RNA interference<\/em> (RNAi)<\/strong>, emphasizing that siRNAs are an important tool in mammals for silencing specific genes, and discusses experimental and therapeutic applications \u2014 from functional studies to early clinical trials of RNA\u2011based drugs. The authors comment on the potential of miRNAs as biomarkers<\/strong> and RNAi approaches as promising therapeutic strategies<\/strong>, while also pointing out technical limitations (target prediction specificity, need for experimental validation) and challenges for clinical translation.<\/p>\n

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About Genetics and Molecular Biology<\/em><\/strong><\/h3>\n

GMB was published between 1978 and 1997 under the title Revista Brasileira de Gen\u00e9tica<\/em> (Brazilian Journal of Genetics<\/em>), and its name was updated to Genetics and Molecular Biology<\/em> starting with volume 21, issue 01, March 1998. In 2024, the journal obtained an impact factor of 1.3 (1.7 for 5 years \/ JCR, Clarivate), with a Citescore of 3.2 and an h\u2011Index of 65.<\/p>\n

 <\/p>\n<\/i> Read the full paper on ncRNAs<\/span><\/a>\n

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Sorry, this entry is only available in Brazilian Portuguese.<\/p>\n","protected":false},"author":13,"featured_media":17021,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pgc_meta":""},"categories":[997],"tags":[698,1043,661,1044,1042,1046,1047,1045,1041],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t